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Article

Association of longevity with TNF-α G308A and IL-6 G174C polymorphic inflammatory biomarkers in Caucasians: a meta-analysis.

Zeitschrift fur Gerontologie und Geriatrie - 1 Dec 2016

Wei Gan-Zhong, Wang Fang, Zhao Yue-Guang, Li Shan-Shan, Shi Min-Ling, Gao Kang, Luo Ying, Tang Wen-Ru

Abstract excerpt

BACKGROUND: Mutations in genes encoding tumor necrosis factor (TNF)-α and interleukin (IL)-6 were previously shown to affect mortality. Single nucleotide polymorphisms (SNPs) in the functional promoter regions of TNF-α (G308A) and IL-6 (G174C) are among the most widely studied. OBJECTIVES: To determine whether TNF-α G308A and IL-6 G174C SNPs confer susceptibility to longevity, we performed a meta-analysis to...

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PMID: 26754162
DOI: 10.1007/s00391-015-0992-y

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TNF

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