Article
Premature aging in mice deficient in DNA repair and transcription.
Science (New York, N.Y.) - 17 May 2002
de Boer Jan, Andressoo Jaan Olle, de Wit Jan, Huijmans Jan, Beems Rudolph B, van Steeg Harry, Weeda Geert, van der Horst Gijsbertus T J, van Leeuwen Wibeke, Themmen Axel P N, Meradji Morteza, Hoeijmakers Jan H J
Abstract excerpt
One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in XPD, a gene encoding a DNA helicase that functions in both repair and transcription and that is mutated in the human disorder trichothiodystrophy (TTD). TTD mice were found to exhibit many symptoms of premature aging,...
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