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Article

Alpha-tocopherol transfer protein deficiency in mice causes multi-organ deregulation of gene networks and behavioral deficits with age.

Annals of the New York Academy of Sciences - 1 Dec 2004

Gohil Kishorchandra, Godzdanker Roy, O'Roark Erin, Schock Bettina C, Kaini Ramesh R, Packer Lester, Cross Carroll E, Traber Maret G

Abstract excerpt

Functions of alpha-tocopherol (alpha-T) in vivo, other than those for fertility in females, are intensely debated. The discovery of alpha-T deficiency in patients with ataxia (AVED) followed by the identification of mutations in the gene encoding alpha-tocopherol transfer protein (TTP) in AVED patients demonstrates an essential role of alpha-T and TTP for normal neurological function. alpha-T molecular targets...

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Identifiers

PMID: 15753139
DOI: 10.1196/annals.1331.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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