Article
Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.
PloS one - 1 Jan 2015
Zhu Jun, Hou Qiang, Dong Xiang Da, Wang Zhenlian, Chen Xiaoyan, Zheng Dandan, Zhou Linglin, He Chao, Liu Mingyao, Tu LiLi, Qu Jia
Abstract excerpt
Oxidative stress contributes to the formation of cataracts. The leucine rich repeat containing G protein-coupled receptor 4 (LGR4, also known as GPR48), is important in many developmental processes. Since deletion of Lgr4 has previously been shown to lead to cataract formation in mice, we sought to determine the specific role that Lgr4 plays in the formation of cataracts. Initially, the lens opacities of...
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