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Article

Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis.

Annals of the rheumatic diseases - 1 Aug 2011

Hinks Anne, Moncrieffe Halima, Martin Paul, Ursu Simona, Lal Sham, Kassoumeri Laura, Weiler Tracey, Glass David N, Thompson Susan D, Wedderburn Lucy R, Thomson Wendy

Abstract excerpt

OBJECTIVES: Methotrexate (MTX) is the mainstay treatment for juvenile idiopathic arthritis (JIA), however approximately 30% of children will fail to respond to the drug. Identification of genetic predictors of response to MTX would be invaluable in developing optimal treatment strategies for JIA. Using a candidate gene approach, single nucleotide polymorphisms (SNPs) within genes in the metabolic pathway of MTX,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21515602
DOI: 10.1136/ard.2010.146191
PMCID: PMC3128324

Genes

ATIC
ACR
ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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