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Article

Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype.

Pharmacogenetics and genomics - 1 Nov 2010

Moncrieffe Halima, Hinks Anne, Ursu Simona, Kassoumeri Laura, Etheridge Angela, Hubank Mike, Martin Paul, Weiler Tracey, Glass David N, Thompson Susan D, Thomson Wendy, Wedderburn Lucy R

Abstract excerpt

OBJECTIVES: Little is known about the mechanisms of efficacy of methotrexate (MTX) in childhood arthritis, or genetic influences upon response to MTX. The aims of this study were to use gene expression profiling to identify novel pathways/genes altered by MTX and then investigate these genes for genotype associations with response to MTX treatment. METHODS: Gene expression profiling before and after MTX treatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20827233
DOI: 10.1097/FPC.0b013e32833f2cd0
PMCID: PMC2963015

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ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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