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Article

The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.

Arthritis and rheumatism - 1 Jan 2011

Becker Mara L, Gaedigk Roger, van Haandel Leon, Thomas Bradley, Lasky Andrew, Hoeltzel Mark, Dai Hongying, Stobaugh John, Leeder J Steven

Abstract excerpt

OBJECTIVE: The response to and toxicity of methotrexate (MTX) are unpredictable in patients with juvenile idiopathic arthritis (JIA). Intracellular polyglutamation of MTX, assessed by measuring concentrations of MTX polyglutamates (MTXGlu), has been demonstrated to be a promising predictor of drug response. Therefore, this study was aimed at investigating the genetic predictors of MTXGlu variability and...

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Source

Identifiers

PMID: 20954192
DOI: 10.1002/art.30080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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