From growing to secreting: New roles for mTOR in aging cells

Abstract excerpt

Deregulation of the nutrient sensitive mTOR signaling pathway has been recently involved in several age-related diseases, and pharmacological blockade of mTOR extends longevity in model organisms and in mice. Mechanistic studies in vitro have shed light on the role of mTOR-dependent growth signals in promoting senescence and exhaustion of quiescent stem cells, thus linking excess nutrients to tissue ageing. Novel...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Genetics, Aging, and Longevity in Model Organisms