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Article

Flies without a spindle checkpoint.

Nature cell biology - 1 May 2007

Buffin Eulalie, Emre Doruk, Karess Roger E

Abstract excerpt

Mad2 has a key role in the spindle-assembly checkpoint (SAC) - the mechanism delaying anaphase onset until all chromosomes correctly attach to the spindle. Here, we show that unlike every other reported case of SAC inactivation in metazoans, mad2-null Drosophila are viable and fertile, and their cells almost always divide correctly despite having no SAC and an accelerated 'clock', which is caused by premature...

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PMID: 17417628
DOI: 10.1038/ncb1570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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