Article
Gender differences in the risk of familial parkinsonism: beyond LRRK2?
Neuroscience letters - 1 Jun 2011
Saunders-Pullman R, Stanley K, San Luciano M, Barrett M J, Shanker V, Raymond D, Ozelius L J, Bressman S B
Abstract excerpt
G2019S mutations in the LRRK2 gene are responsible for up to 18% of PD in individuals of Jewish descent. While a male preponderance of Parkinson disease (PD) has been consistently reported, this gender difference is not noted in LRRK2 G2019S mutation carriers. In order to test whether there is an increased genetic component in women of Jewish background in general, we examined family history of parkinsonism in...
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