Article
LRRK2 mutations in Parkinson's disease: confirmation of a gender effect in the Italian population.
Parkinsonism & related disorders - 1 Aug 2014
Cilia Roberto, Siri Chiara, Rusconi Damiana, Allegra Roberta, Ghiglietti Andrea, Sacilotto Giorgio, Zini Michela, Zecchinelli Anna L, Asselta Rosanna, Duga Stefano, Paganoni Anna M, Pezzoli Gianni, Seia Manuela, Goldwurm Stefano
Abstract excerpt
BACKGROUND: The relative risk of developing idiopathic PD is 1.5 times greater in men than in women, but an increased female prevalence in LRRK2-carriers has been described in the Ashkenazi Jewish population. We report an update about the frequency of major LRRK2 mutations in a large series of consecutive patients with Parkinson's disease (PD), including extensive characterization of clinical features. In...
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