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Article

Synergistic activation of human natural killer cell cytotoxicity by histamine and interleukin-2.

International archives of allergy and applied immunology - 1 Jan 1990

Hellstrand K, Hermodsson S

Abstract excerpt

Interleukin-2 (IL-2) is recognized as a major activating signal for human natural killer (NK) cells. The presence of monocytes alters NK cell responsiveness to IL-2. Thus, while IL-2 effectively augments NK cell cytotoxicity (NKCC) in monocyte-depleted NK effector cells, it is relatively ineffective or even suppressive for NK cells in monocyte-containing, NK-cell-enriched mononuclear cell fractions. Here we...

Topics

Antigens, Differentiation
Antigens, Differentiation, T-Lymphocyte
CD3 Complex
Cytotoxicity, Immunologic
Drug Synergism
Histamine
Humans
Interferon-gamma
Interleukin-2
Killer Cells, Natural
Monocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Antigen, T-Cell

Receptors, Fc

Receptors, Histamine H2

Receptors, IgG

Source

Identifiers

PMID: 2150668
DOI: 10.1159/000235169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2150668-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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