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Article

Monocyte-mediated suppression of IL-2-induced NK-cell activation. Regulation by 5-HT1A-type serotonin receptors.

Scandinavian journal of immunology - 1 Aug 1990

Hellstrand K, Hermodsson S

Abstract excerpt

In the present study, the effects of serotonin on human natural killer (NK)-cell responsiveness to interleukin 2 (IL-2) was investigated. Concomitant treatment of human lymphocytes, enriched for NK effector cells by Percoll density-gradient centrifugation, with serotonin and IL-2 yielded a synergistic activation of NK-cell cytotoxicity (NKCC) in the presence but not in the absence of monocytes. The...

Topics

Cell Separation
Cyclooxygenase Inhibitors
Cytotoxicity, Immunologic
Drug Synergism
Humans
Indomethacin
Interleukin-2
Killer Cells, Natural
Lymphocyte Activation
Monocytes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Serotonin

Recombinant Proteins

Serotonin

Tetrahydronaphthalenes

Source

Identifiers

PMID: 2117776
DOI: 10.1111/j.1365-3083.1990.tb02908.x

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2117776-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Monocyte-mediated suppression of IL-2-induced NK-cell activation. Regulation by 5-HT1A-type serotonin receptors.PMID 2117776Read ↗

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