Reversal of lovastatin-mediated inhibition of natural killer cell cytotoxicity by interleukin 2.

doi:10.1002/jcp.1041450208

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Article

Reversal of lovastatin-mediated inhibition of natural killer cell cytotoxicity by interleukin 2.

Journal of cellular physiology - 1 Nov 1990

Cutts J L, Bankhurst A D

Abstract excerpt

The activation of human natural killer (NK) cell cytotoxicity by interleukin 2 (IL-2) is well established, although the biochemical mechanisms of this stimulation have not yet been fully delineated. Earlier, we reported that treatment of NK cells with an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase such as compactin or lovastatin significantly abrogates the in vitro killing of a...

Topics

Acetates
Antibody-Dependent Cell Cytotoxicity
Chemotaxis, Leukocyte
Cholesterol
Cytotoxicity, Immunologic
DNA Replication
Humans
In Vitro Techniques
Interleukin-2
Killer Cells, Natural
Lovastatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mannose

Mevalonic Acid

Phenotype

Protein Biosynthesis

Thymidine

Time Factors

Tritium

Source

Open in PubMed

Identifiers

PMID: 2246324
DOI: 10.1002/jcp.1041450208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2246324-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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