Article
Natural killer cells activate human dermal fibroblasts.
Cytokine - 1 Dec 2000
Müller K M, Bickel M, Wiesmann U N, Spörri B
Abstract excerpt
Human dermal fibroblasts (HDF) undergo activation and secrete cytokines when cocultured with T cells. Here, we identify potent activators of HDF among human peripheral CD2(+)-lymphocytes. Populations with strong HDF activating capacity consisted essentially of cells with a natural killer (NK) surface marker phenotype (CD3(-), CD4(-), CD8(-), CD56(+)). Addition of these cells to HDF resulted in rapid increase of...
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