Article
Regulation of the natural killer cell response to interferon-alpha by biogenic amines.
Journal of interferon research - 1 Jun 1992
Hellstrand K, Kylefjord H, Asea A, Hermodsson S
Abstract excerpt
Monocytes, recovered from human peripheral blood by counter-current centrifugal elutriation (CCE), suppressed baseline natural killer (NK) cell cytotoxicity (NKCC) and rendered NK cells resistant to activation of cytotoxicity by human recombinant interferon-alpha (IFN-alpha) by a cell contact-dependent mechanism. Monocyte-induced suppression of resting and IFN-activated NK cells was abrogated by the biogenic...
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