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Article

Regulation of the natural killer cell response to interferon-alpha by biogenic amines.

Journal of interferon research - 1 Jun 1992

Hellstrand K, Kylefjord H, Asea A, Hermodsson S

Abstract excerpt

Monocytes, recovered from human peripheral blood by counter-current centrifugal elutriation (CCE), suppressed baseline natural killer (NK) cell cytotoxicity (NKCC) and rendered NK cells resistant to activation of cytotoxicity by human recombinant interferon-alpha (IFN-alpha) by a cell contact-dependent mechanism. Monocyte-induced suppression of resting and IFN-activated NK cells was abrogated by the biogenic...

Topics

Cell Adhesion
Cell Communication
Cell Separation
Centrifugation, Density Gradient
Cytotoxicity, Immunologic
Drug Synergism
Histamine
Humans
Interferon Type I
Killer Cells, Natural
Monocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Recombinant Proteins

Serotonin

T-Lymphocytes

Tumor Cells, Cultured

Source

Identifiers

PMID: 1640122
DOI: 10.1089/jir.1992.12.199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1640122-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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