Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of human natural killer cell cytotoxicity by serotonin: role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptors.

Cellular immunology - 15 Apr 1990

Hellstrand K, Hermodsson S

Abstract excerpt

Serotonin (10(-4) - 10(-7) M) augmented natural killer cell cytotoxicity (NKCC) of human CD16+/non-T lymphocytes in vitro against the NK-sensitive target cells K 562 erythroleukemic, Molt-4 lymphoma, Chang liver cells, and against EBV-transformed Daudi B-lymphoblastoid target cells by a mechanism of action involving a prostaglandin-and IL-1-independent accessory function of monocytes. No evidence for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation
Share to Cytokines
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lymphoma

Share to Monocytes

Share to Phenotype

Share to T-Lymphocytes

Source

Identifiers

PMID: 2138518
DOI: 10.1016/0008-8749(90)90125-b

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Enhancement of human natural killer cell cytotoxicity by serotonin: role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptors.PMID 2138518Read ↗

A cell-to-cell mediated interaction involving monocytes and non-T/CD16+ natural killer (NK) cells is required for histamine H2-receptor-mediated NK-cell activation.Semantic proximity Read ↗

Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes.Semantic proximity Read ↗

Monocyte-mediated suppression of IL-2-induced NK-cell activation. Regulation by 5-HT1A-type serotonin receptors.Semantic proximity Read ↗

Regulation of the natural killer cell response to interferon-alpha by biogenic amines.Semantic proximity Read ↗

Synergistic activation of human natural killer cell cytotoxicity by histamine and interleukin-2.Semantic proximity Read ↗

Effect of Salmonella-infected human monocytes on natural killer cell cytotoxicity. In vitro studies.Semantic proximity Read ↗

Paradoxical enhancement of interleukin-2-mediated cytotoxicity against K562 cells by addition of a low dose of methotrexate.Semantic proximity Read ↗

Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.