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Article

CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity

29 Jan 2010

Abstract excerpt

BACKGROUND: Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date. METHODOLOGY: To uncover genetic dependencies in breast cancer cells that harbor active beta-catenin signaling, we performed RNAi-based loss-of-function screens in breast cancer cell...

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PMID: 20126544
DOI: 10.1371/journal.pone.0008979

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