Article
Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Cell death and differentiation - 1 Jun 2005
Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, Pinna L A, Ruzzene M
Abstract excerpt
Treatment of Jurkat cells with specific inhibitors of protein kinase CK2 induces apoptosis. Here we provide evidence that the anti-apoptotic effect of CK2 can be at least partially mediated by upregulation of the Akt/PKB pathway. Such a conclusion is based on the following observations: (1) inhibition of CK2 by cell treatment with two structurally unrelated CK2 inhibitors induces downregulation of Akt/PKB, as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.