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Article

Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes.

The Journal of biological chemistry - 21 Jul 2017

Duong Michelle, Yu Xuejiao, Teng Beina, Schroder Patricia, Haller Hermann, Eschenburg Susanne, Schiffer Mario

Abstract excerpt

Kidney disease has been linked to dysregulated signaling via PKC in kidney cells such as podocytes. PKCα is a conventional isoform of PKC and a well-known binding partner of β-catenin, which promotes its degradation. β-Catenin is the main effector of the canonical Wnt pathway and is critical in cell adhesion. However, whether other PKC isoforms interact with β-catenin has not been studied systematically. Here we...

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Identifiers

PMID: 28539358
DOI: 10.1074/jbc.M117.775700
PMCID: PMC5519362

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