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Article

Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells

10 Nov 2010

Abstract excerpt

Resistance to the antiestrogen tamoxifen remains a major problem in the management of estrogen receptor-positive breast cancer. Knowledge on the resistance mechanisms is needed to develop more effective therapies. Breast cancer antiestrogen resistance 4 (BCAR4) was identified in a functional screen for genes involved in tamoxifen resistance. BCAR4 is expressed in 27% of primary breast tumors. In patients treated...

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PMID: 21506106
DOI: 10.1002/jcp.22503

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