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Article

BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.

Journal of the National Cancer Institute - 19 Jan 2000

Brinkman A, van der Flier S, Kok E M, Dorssers L C

Abstract excerpt

BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of metastases that are resistant to tamoxifen. We have previously shown that mutagenesis of human estrogen-dependent ZR-75-1 breast cancer cells by insertion of a defective retrovirus genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10639512
DOI: 10.1093/jnci/92.2.112

Genes

BCAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.PMID 10639512Read ↗

Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cellsSemantic proximity Read ↗

Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.Semantic proximity Read ↗

Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma CellsSemantic proximity Read ↗

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Functional Screen for Genes Responsible for Tamoxifen Resistance in Human Breast Cancer CellsSemantic proximity Read ↗

AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer CellsSemantic proximity Read ↗

Global Gene Repression by the Steroid Receptor Coactivator SRC-1 Promotes OncogenesisSemantic proximity Read ↗

Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathwaySemantic proximity Read ↗

Amplified in Breast Cancer 1 in Human Epidermal Growth Factor Receptor–Positive Tumors of Tamoxifen-Treated Breast Cancer PatientsSemantic proximity Read ↗

BCAR1/p130Cas expression in untreated and acquired tamoxifen-resistant human breast carcinomasSemantic proximity Read ↗

Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice.Semantic proximity Read ↗

Role of the Nuclear Receptor Coactivator AIB1-Δ4 Splice Variant in the Control of Gene TranscriptionSemantic proximity Read ↗

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