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Article

The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens.

Arthritis and rheumatism - 1 Jul 2011

Willemze Annemiek, van der Woude Diane, Ghidey Wendimagegn, Levarht E W Nivine, Stoeken-Rijsbergen Gerrie, Verduyn Willem, de Vries René R P, Houwing-Duistermaat Jeanine J, Huizinga Tom W J, Trouw Leendert A, Toes René E M

Abstract excerpt

OBJECTIVE: Recent data suggest that a gene-environment interaction between smoking and the HLA shared epitope alleles plays a role in shaping the autoimmune reaction to specific citrullinated antigens. This study was undertaken to determine the effects of HLA shared epitope alleles and tobacco exposure on the immune response against various citrullinated antigens. These associations were analyzed in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21506097
DOI: 10.1002/art.30409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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