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Article

Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts.

Arthritis and rheumatism - 1 Jun 2007

Lee Hye-Soon, Irigoyen Patricia, Kern Marlena, Lee Annette, Batliwalla Franak, Khalili Houman, Wolfe Frederick, Lum Raymond F, Massarotti Elena, Weisman Michael, Bombardier Claire, Karlson Elizabeth W, Criswell Lindsey A, Vlietinck Robert, Gregersen Peter K

Abstract excerpt

OBJECTIVE: Recently, Swedish members of the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) provided evidence that smoking may trigger RA-specific immune reactions to citrullinated protein in carriers of HLA-DR shared epitope alleles. In an effort to confirm this interaction between smoking and shared epitope alleles, we performed a case-only analysis of 3 North American RA cohorts. METHODS: A total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17530703
DOI: 10.1002/art.22703

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Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts.PMID 17530703Read ↗

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