Article
Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins.
Annals of the rheumatic diseases - 1 Feb 2015
Hensvold Aase Haj, Magnusson Patrik K E, Joshua Vijay, Hansson Monika, Israelsson Lena, Ferreira Ricardo, Jakobsson Per-Johan, Holmdahl Rikard, Hammarström Lennart, Malmström Vivianne, Askling Johan, Klareskog Lars, Catrina Anca Irinel
Abstract excerpt
OBJECTIVE: To investigate the role of genetic and environmental factors in the development of anticitrullinated protein antibodies (ACPA) and ACPA-positive rheumatoid arthritis (RA) in a twin cohort. METHODS: A total of 12 590 twins were analysed for the presence of ACPAs (CCP2 ELISA), HLA-DRB1 shared epitope (SE) gene alleles, and exposure to smoking. Twins with established RA were identified in national public...
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