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Article

Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.

Nature genetics - 1 Dec 2009

Mahdi Hiba, Fisher Benjamin A, Källberg Henrik, Plant Darren, Malmström Vivianne, Rönnelid Johan, Charles Peter, Ding Bo, Alfredsson Lars, Padyukov Leonid, Symmons Deborah P M, Venables Patrick J, Klareskog Lars, Lundberg Karin

Abstract excerpt

Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with an association existing between smoking, HLA- DRB1 'shared epitope' alleles, PTPN22 and antibodies to cyclic citrullinated peptides (CCP). Here, we test the hypothesis that a subset of the anti-CCP response, with specific autoimmunity to citrullinated alpha-enolase, accounts for an important portion of these...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Source

Identifiers

PMID: 19898480
DOI: 10.1038/ng.480

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.PMID 19898480Read ↗

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