Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.

Seminars in immunology - 1 Apr 2011

Klareskog Lars, Malmström Vivianne, Lundberg Karin, Padyukov Leonid, Alfredsson Lars

Abstract excerpt

This review describes how studies on interactions between genetic variants, and environmental factors, mainly smoking, contribute to the understanding of how autoimmunity to post-translationally (citrullinated) proteins/peptides may occur and potentially contribute to certain subsets of rheumatoid arthritis. A main message is that studies on specific immune mechanisms in a complex and heterogeneous disease like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Citrulline
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monoclonal and Polyclonal Antibodies Research

Share to Rheumatoid Arthritis Research and Therapies

Share to Smoking

Share to Systemic Lupus Erythematosus Research

Source

Identifiers

PMID: 21376627
DOI: 10.1016/j.smim.2011.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.PMID 21376627Read ↗

New insights into the genetics of immune responses in rheumatoid arthritis.Semantic proximity Read ↗

Genes, environment and immunity in the development of rheumatoid arthritis.Semantic proximity Read ↗

A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullinationSemantic proximity Read ↗

HLA and anti-citrullinated protein antibodies: Building blocks in RA.Semantic proximity Read ↗

Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis.Semantic proximity Read ↗

Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis.Semantic proximity Read ↗

Current concepts in the pathogenesis of early rheumatoid arthritis.Semantic proximity Read ↗

Genetics of rheumatoid arthritis: what have we learned?Semantic proximity Read ↗

Rheumatoid arthritis and smoking: putting the pieces together.Semantic proximity Read ↗

Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritisSemantic proximity Read ↗

The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review.Semantic proximity Read ↗

Immunity to Citrullinated Proteins in Rheumatoid ArthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.