Article
Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
Gastroenterology - 1 Jan 2013
Carvajal-Carmona Luis G, Zauber Ann G, Jones Angela M, Howarth Kimberley, Wang Jiping, Cheng Timothy, Riddell Robert, Lanas Angel, Morton Dion, Bertagnolli Monica M, Tomlinson Ian
Abstract excerpt
Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, , , and ) were over-represented in CRC-free patients with...