Article
Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan.
The Chinese journal of physiology - 31 Dec 2009
Bau Da-Tian, Wang Hwei-Chung, Liu Chiu-Shong, Chang Chia-Lin, Chiang Su-Yin, Wang Rou-Fen, Tsai Chia-Wen, Lo Yen-Li, Hsiung Chao A, Lin Cheng-Chieh, Huang Chih-Yang
Abstract excerpt
Exonuclease 1 (Exo1) is an important nuclease involved in the mismatch repair system that contributes to the maintenance of genomic stability, modulation of DNA recombination and mediation of cell cycle arrest. Potential polymorphisms in Exo1 may alter cancer risks by influencing the repair activity of Exo1. We hypothesized that single-nucleotide polymorphisms (SNPs) in Exo1 might be associated with risks of...
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