Article
Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan.
Oral oncology - 1 Sept 2009
Tsai Ming-Hsui, Tseng Hsien-Chang, Liu Chiu-Shong, Chang Chia-Lin, Tsai Chia-Wen, Tsou Yung-An, Wang Rou-Fen, Lin Cheng-Chieh, Wang Hwei-Chung, Chiu Chang-Fang, Bau Da-Tian
Abstract excerpt
Exonuclease 1 (Exo1) is an important nuclease involved in the mismatch repair system that helps to maintain genomic stability, to modulate DNA recombination, and to mediate cell cycle arrest. Potential polymorphisms in Exo1 may alter cancer risks by influencing the repair activity of Exo1. Therefore, we hypothesized that single-nucleotide polymorphisms in Exo1 were associated with the risk of oral cancer. In this...
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