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Article

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Knudsen Erik S, McClendon A Kathleen, Franco Jorge, Ertel Adam, Fortina Paolo, Witkiewicz Agnieszka K

Abstract excerpt

Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with the analysis of clinical specimens. Primary mouse mammary epithelial cells (mMEC) with defined genetic features were used to delineate the combined action of RB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mice, Nude

Share to Mitogen-Activated Protein Kinase Kinases

Share to Proto-Oncogene Proteins c-myc

Share to Retinoblastoma Protein

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25602521
DOI: 10.4161/15384101.2014.967118
PMCID: PMC4353068

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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