Article
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.
Journal of molecular medicine (Berlin, Germany) - 1 Oct 2011
Kisseleva Tatiana, von Köckritz-Blickwede Maren, Reichart Donna, McGillvray Shauna M, Wingender Gerhard, Kronenberg Mitchell, Glass Christopher K, Nizet Victor, Brenner David A
Abstract excerpt
Bone marrow (BM)-derived fibrocytes are a population of CD45(+) and collagen Type I-expressing cells that migrate to the spleen and to target injured organs, such as skin, lungs, kidneys, and liver. While CD45(+)Col(+) fibrocytes contribute to collagen deposition at the site of injury, the role of CD45(+)Col(+) cells in spleen has not been elucidated. Here, we demonstrate that hepatotoxic injury (CCl(4)), TGF-β1,...
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