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The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

21 May 2014

Abstract excerpt

A prerequisite for establishment of mutualism between the host and the microbial community that inhabits the large intestine is the stringent mucosal compartmentalization of microorganisms. Microbe-loaded dendritic cells trafficking through lymphatics are arrested at the mesenteric lymph nodes, which constitute the firewall of the intestinal lymphatic circulation. We show in different mouse models that the liver,...

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PMID: 24848256
DOI: 10.1126/scitranslmed.3008618

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