Article
Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2003
Rudner Lynnie A, Lin Jack T, Park Il-Kyoo, Cates Justin M M, Dyer Darci A, Franz Douglas M, French Margaret A, Duncan Elizabeth M, White Hillary D, Gorham James D
Abstract excerpt
The etiology of autoimmune liver disease is poorly understood. BALB/c mice deficient in the immunoregulatory cytokine TGF-beta1 spontaneously develop necroinflammatory liver disease, but the immune basis for the development of this pathology has not been demonstrated. Here, we show that BALB/c-TGF-beta1(-/-) mice exhibit abnormal expansion in hepatic mononuclear cells (MNCs) compared with wild-type littermate...
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