Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

22 Aug 2018

Abstract excerpt

Loss of WW domain-containing oxidoreductase (Wwox) expression has been observed in breast cancer (BC). However, its regulatory effects are largely unknown, especially in triple-negative breast cancer (TNBC). Herein, gene expression profiling revealed that JAK/STAT3 pathway was one of the most differentially modulated pathways in basal-like BC cells. The lower expression of Wwox was significantly correlated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular RNAs in diseases
Share to Cytokine Signaling Pathways and Interactions
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30154439
DOI: 10.1038/s41467-018-05852-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axisPMID 30154439Read ↗

Wwox inactivation enhances mammary tumorigenesis.Semantic proximity Read ↗

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOXSemantic proximity Read ↗

Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3Semantic proximity Read ↗

WWP1 E3 ligase at the crossroads of health and diseaseSemantic proximity Read ↗

WSB1 promotes tumor metastasis by inducing pVHL degradation.Semantic proximity Read ↗

The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype.Semantic proximity Read ↗

RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axisSemantic proximity Read ↗

WBP2 Negatively Regulates Hippo Pathway By Competitively Binding To WWC3 With LATS1 To Promote The Malignant Phenotype Of Non-Small Cell Lung CancerSemantic proximity Read ↗

Potential therapeutic targets of the JAK2/STAT3 signaling pathway in triple-negative breast cancerSemantic proximity Read ↗

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.Semantic proximity Read ↗

C/EBPβ regulates the JAK/STAT signaling pathway in triple‐negative breast cancerSemantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.