Article
Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007
Gorman Shelley, Kuritzky L Alexandra, Judge Melinda A, Dixon Katie M, McGlade Jacqueline P, Mason Rebecca S, Finlay-Jones John J, Hart Prue H
Abstract excerpt
The immunomodulatory effects of vitamin D have been described following chronic oral administration to mice or supplementation of cell cultures with 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D. In this study, topically applied 1,25(OH)(2)D(3), enhanced the suppressive capacity of CD4(+)CD25(+) cells from the draining lymph nodes. The effects of topical 1,25(OH)(2)D(3) were compared...
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