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Article

Protein inhibitor of activated STAT3 expression in lung cancer.

Molecular oncology - 1 Jun 2011

Kluge Amy, Dabir Snehal, Vlassenbroeck Ilse, Eisenberg Rosana, Dowlati Afshin

Abstract excerpt

Protein Inhibitor of Activated Signal Transducer and Activators of Transcription 3 (PIAS3) is an endogenous inhibitor of STAT3 transcriptional activity. We have previously demonstrated the concentration-dependent negative regulatory effect of PIAS3 on STAT3 signaling and its capacity to decrease lung cancer proliferation and synergize with epidermal growth factor inhibition. We now investigate PIAS3 expression in...

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Source

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Identifiers

PMID: 21497567
DOI: 10.1016/j.molonc.2011.03.004
PMCID: PMC3104085

Genes

PIAS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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