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Article

Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2005

Haura Eric B, Zheng Zhong, Song Lanxi, Cantor Alan, Bepler Gerold

Abstract excerpt

PURPOSE: Signal transducers and activators of transcription 3 (Stat3), a member of the STAT family of transcription factors, regulates multiple oncogenic pathways, including pathways regulating tumor cell survival. We evaluated Stat3 activation in early stage non-small cell lung cancers (NSCLC) and how this relates to upstream epidermal growth factor receptor (EGFR) activation, tumor apoptosis, and prognosis....

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Source

Identifiers

PMID: 16322287
DOI: 10.1158/1078-0432.CCR-05-0827

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer.PMID 16322287Read ↗

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