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Article

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

14 Nov 2003

Abstract excerpt

Lung cancer is the leading cause of cancer death in the world, but the molecular mechanisms for its development have not been well characterized. The suppressors of cytokine signaling (SOCS) are inhibitors of cytokine signaling that function via the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway. Eight SOCS proteins with similar structures have been identified so far. SOCS...

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PMID: 14617776
DOI: 10.1073/pnas.2232790100

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