Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.

doi:10.1182/blood-2005-08-3325

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Article

Identifying a common molecular mechanism for inhibition of MITF and STAT3 by PIAS3.

Blood - 1 Apr 2006

Levy Carmit, Lee Yu-Nee, Nechushtan Hovav, Schueler-Furman Ora, Sonnenblick Amir, Hacohen Shelley, Razin Ehud

Abstract excerpt

Protein inhibitor of activated STAT3 (PIAS3) functions in vivo as a key molecule in suppressing the transcriptional activity of both microphthalmia transcription factor (MITF) and signal transducer and activator of transcription 3 (STAT3), 2 transcription factors that play a major role in the regulation of growth and function in mast cells and melanocytes. Previously, we have demonstrated binding of PIAS3 to MITF...

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Source

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Identifiers

PMID: 16368885
DOI: 10.1182/blood-2005-08-3325

Genes

MITF
PIAS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.