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Article

PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4

1 Jun 2003

Abstract excerpt

In response to interleukin 12 (IL-12) stimulation, a latent cytoplasmic transcription factor, Stat4 (signal transducer and activator of transcription 4), becomes tyrosine-phosphorylated and translocates into the nucleus where it binds to DNA to activate transcription. Cofactors that can directly bind and regulate Stat4 activity have not been described. We report here that PIASx, a member of the protein inhibitor...

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PMID: 12716907
DOI: 10.1074/jbc.c300119200

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