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The Heparan Sulfate Proteoglycan <i>GPC3</i> Is a Potential Lung Tumor Suppressor

23 Jun 2003

Abstract excerpt

Recently, we used gene expression profiling of lung adenocarcinoma and paired normal tissue from smokers and nonsmokers to identify genes and molecular pathways associated with cigarette smoking and lung carcinogenesis. The gene encoding Glypican 3, a glycosylphosphatidylinositol-linked heparan sulfate proteoglycan, was decreased in lung adenocarcinoma. Within nonmalignant lung, GPC3 expression was decreased in...

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PMID: 12816733
DOI: 10.1165/rcmb.2003-0061oc

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