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Fetal haemoglobin induction in sickle cell disease

16 Nov 2017

Abstract excerpt

Fetal haemoglobin (HbF, α2γ2) induction has long been an area of investigation, as it is known to ameliorate the clinical complications of sickle cell disease (SCD). Progress in identifying novel HbF-inducing strategies has been stymied by limited understanding of gamma (γ)-globin regulation. Genome-wide association studies (GWAS) have identified variants in BCL11A and HBS1L-MYB that are associated with HbF...

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Share to Epigenetics and DNA Methylation
Share to Hemoglobinopathies and Related Disorders
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PMID: 29143315
DOI: 10.1111/bjh.15021

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