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Article

Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells.

Biochimica et biophysica acta - 1 Jan 2007

Tsuzuki Tsuyoshi, Kambe Tomoko, Shibata Akira, Kawakami Yuki, Nakagawa Kiyotaka, Miyazawa Teruo

Abstract excerpt

Both conjugated linoleic acid (CLA), which contains conjugated double bonds, and eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, have antitumor effects. Hence, we hypothesized that a combination of conjugated double bonds and an n-3 highly unsaturated fatty acid may produce a stro...

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Source

Identifiers

PMID: 17196878
DOI: 10.1016/j.bbalip.2006.11.006

Genes

DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17196878-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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