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Article

Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice.

Molecular genetics and metabolism - 1 Dec 2007

Shekhawat Prem S, Srinivas Sonne R, Matern Dietrich, Bennett Michael J, Boriack Richard, George Varghese, Xu Hongyan, Prasad Puttur D, Roon Penny, Ganapathy Vadivel

Abstract excerpt

Carnitine is essential for transport of long-chain fatty acids into mitochondria for their subsequent beta-oxidation, but its role in the gastrointestinal tract has not been well described. Recently several genetic epidemiologic studies have shown strong association between mutations in carnitine transporter genes OCTN1 and OCTN2 and a propensity to develop Crohn's disease. This study aims to investigate role of...

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Identifiers

PMID: 17884651
DOI: 10.1016/j.ymgme.2007.08.002
PMCID: PMC2170531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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