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Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer Cells

18 Aug 2005

Abstract excerpt

The mitochondrial enzyme manganese superoxide dismutase (MnSOD) is known to suppress cell growth in different tumor cell lines. However, the molecular mechanism of this growth-retarding effect is not fully understood. Here we show that overexpression of MnSOD slows down growth of HCT116 human colorectal cancer cells by induction of cellular senescence. MnSOD overexpression causes up-regulation of p53 and its...

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PMID: 16107721
DOI: 10.1128/mcb.25.17.7758-7769.2005

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