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Article

Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response.

PloS one - 1 Jan 2012

Sonne Srinivas, Shekhawat Prem S, Matern Dietrich, Ganapathy Vadivel, Ignatowicz Leszek

Abstract excerpt

We have investigated the gross, microscopic and molecular effects of carnitine deficiency in the neonatal gut using a mouse model with a loss-of-function mutation in the OCTN2 (SLC22A5) carnitine transporter. The tissue carnitine content of neonatal homozygous (OCTN2(-/-)) mouse small intestine w...

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Identifiers

PMID: 23112839
DOI: 10.1371/journal.pone.0047729
PMCID: PMC3480427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23112839-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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