Article
Cell fate takes a slug in BRCA1-associated breast cancer.
Breast cancer research : BCR - 6 Apr 2011
Lindeman Geoffrey J, Visvader Jane E
Abstract excerpt
Understanding why BRCA1 mutation carriers have a predilection for developing clinically aggressive basal-like breast tumors could inform the development of targeted treatment or prevention strategies. Analysis of both mouse and human mammary epithelial cells has identified a role for BRCA1 in orchestrating differentiation. The ability to isolate discrete epithelial subpopulations from mammary tissue has recently...
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