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Cancer stem cell heterogeneity in hereditary breast cancer

1 Apr 2008

Abstract excerpt

The cancer stem cell hypothesis proposes that tumors arise in stem or progenitor cells generating in tumors driven by a subcomponent that retains cancer stem cell properties. Recent evidence supports the hypothesis that the BRCA1 gene involved in hereditary breast cancer plays a role in breast stem cell function. Furthermore, studies using mouse BRCA1 knockout models provide evidence for the existence of...

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PMID: 18423071
DOI: 10.1186/bcr1990

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