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Article

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

Nature medicine - 1 Aug 2009

Lim Elgene, Vaillant François, Wu Di, Forrest Natasha C, Pal Bhupinder, Hart Adam H, Asselin-Labat Marie-Liesse, Gyorki David E, Ward Teresa, Partanen Audrey, Feleppa Frank, Huschtscha Lily I, Thorne Heather J, Fox Stephen B, Yan Max, French Juliet D, Brown Melissa A, Smyth Gordon K, Visvader Jane E, Lindeman Geoffrey J

Abstract excerpt

Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers, we have prospectively isolated distinct epithelial subpopulations from normal mammary tissue and preneoplastic specimens from individuals heterozygous for a BRCA1...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Mammary Glands, Human

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Share to Receptors, Progesterone

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Source

Identifiers

PMID: 19648928
DOI: 10.1038/nm.2000

Genes

BRCA1
KIT

Provenance

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